ChloroquineV1, France, Analysis, bibRecord, 000304

Antiplasmodial Phenolic Compounds from Piptadenia pervillei

Identifieur interne : 000304 ( France/Analysis ); précédent : 000303; suivant : 000305

Antiplasmodial Phenolic Compounds from Piptadenia pervillei

Auteurs : Voahangy Ramanandraibe [Madagascar] ; Philippe Grellier [France] ; Marie-Thérèse Martin [France] ; Alexandre Deville [France] ; Roger Joyeau [France] ; David Ramanitrahasimbola [Madagascar] ; Elisabeth Mouray [France] ; Philippe Rasoanaivo [Madagascar] ; Lengo Mambu [France]

Source :

Planta medica [ 0032-0943 ] ; 2008.

RBID : Pascal:08-0207828

Descripteurs français

KwdFr :
- Animaux, Antinéoplasiques d'origine végétale (), Antinéoplasiques d'origine végétale (pharmacologie), Antipaludiques (), Antipaludiques (pharmacologie), Fabaceae (), Humains, Lignée cellulaire, Phénols (), Plasmodium falciparum (), Structure moléculaire.
MESH :
- pharmacologie : Antinéoplasiques d'origine végétale, Antipaludiques.
Pascal (Inist)
- Animaux, Antinéoplasiques d'origine végétale, Antipaludique, Antipaludiques, Fabaceae, Humains, Leguminosae, Lignée cellulaire, Pharmacognosie, Phénols, Plante médicinale, Origine végétale, Antiparasitaire, Catéchine gallate, Plasmodium falciparum, Structure moléculaire.
Wicri :
- topic : Plante médicinale.

English descriptors

KwdEn :
- Animals, Antimalarial, Antimalarials (chemistry), Antimalarials (pharmacology), Antineoplastic Agents, Phytogenic (chemistry), Antineoplastic Agents, Phytogenic (pharmacology), Cell Line, Fabaceae (chemistry), Humans, Leguminosae, Medicinal plant, Molecular Structure, Parasiticide, Pharmacognosy, Phenols (chemistry), Plant origin, Plasmodium falciparum (drug effects).
MESH :
- chemical , chemistry : Antimalarials, Antineoplastic Agents, Phytogenic, Phenols.
- chemical , pharmacology : Antimalarials, Antineoplastic Agents, Phytogenic.
- chemistry : Fabaceae.
- drug effects : Plasmodium falciparum.
- Animals, Cell Line, Humans, Molecular Structure.

Abstract

Piptadenia pervillei Vatke (Fabaceae) was selected from a screening programme devoted to the search of naturally-occuring antimalarial compounds from plants of Madagascar. Bioassay-guided fractionation of the ethyl acetate extract of the leaves led to the isolation of four phenolic compounds, (+)-catechin (1), (+)-catechin 5-gallate (2), (+)-catechin 3-gallate (3) and ethyl gallate (4). Structures were determined by NMR and mass spectroscopy. Compounds 2 and 3 displayed the highest in vitro activity against the chloroquine-resistant strain FcBl of Plasmodium falciparum with IC_so values of 1.2 pM and 1.0 pM, respectively, and no significant cytotoxicity against the human embryonic lung cells MRC-5 was measured (IC₅₀ values >75μM). Five analogues (5-9) of (+)-catechin 5-gallate (2) were synthesized and evaluated for their antiplasmodial activity.

Url:

https://hal.archives-ouvertes.fr/hal-00294805

Affiliations:

Links to Exploration step

Pascal:08-0207828

Le document en format XML

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<author><name sortKey="Ramanitrahasimbola, David" sort="Ramanitrahasimbola, David" uniqKey="Ramanitrahasimbola D" first="David" last="Ramanitrahasimbola">David Ramanitrahasimbola</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Laboratoire de Bio-thérapeutique, Institut Malgache de Recherches Appliquées</s1>
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<author><name sortKey="Mambu, Lengo" sort="Mambu, Lengo" uniqKey="Mambu L" first="Lengo" last="Mambu">Lengo Mambu</name>
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<term>Antimalarial</term>
<term>Antimalarials (chemistry)</term>
<term>Antimalarials (pharmacology)</term>
<term>Antineoplastic Agents, Phytogenic (chemistry)</term>
<term>Antineoplastic Agents, Phytogenic (pharmacology)</term>
<term>Cell Line</term>
<term>Fabaceae (chemistry)</term>
<term>Humans</term>
<term>Leguminosae</term>
<term>Medicinal plant</term>
<term>Molecular Structure</term>
<term>Parasiticide</term>
<term>Pharmacognosy</term>
<term>Phenols (chemistry)</term>
<term>Plant origin</term>
<term>Plasmodium falciparum (drug effects)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Antinéoplasiques d'origine végétale ()</term>
<term>Antinéoplasiques d'origine végétale (pharmacologie)</term>
<term>Antipaludiques ()</term>
<term>Antipaludiques (pharmacologie)</term>
<term>Fabaceae ()</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Phénols ()</term>
<term>Plasmodium falciparum ()</term>
<term>Structure moléculaire</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antimalarials</term>
<term>Antineoplastic Agents, Phytogenic</term>
<term>Phenols</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antimalarials</term>
<term>Antineoplastic Agents, Phytogenic</term>
</keywords>
<keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Fabaceae</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Plasmodium falciparum</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antinéoplasiques d'origine végétale</term>
<term>Antipaludiques</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cell Line</term>
<term>Humans</term>
<term>Molecular Structure</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term>
<term>Antinéoplasiques d'origine végétale</term>
<term>Antipaludique</term>
<term>Antipaludiques</term>
<term>Fabaceae</term>
<term>Humains</term>
<term>Leguminosae</term>
<term>Lignée cellulaire</term>
<term>Pharmacognosie</term>
<term>Phénols</term>
<term>Plante médicinale</term>
<term>Origine végétale</term>
<term>Antiparasitaire</term>
<term>Catéchine gallate</term>
<term>Plasmodium falciparum</term>
<term>Structure moléculaire</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Plante médicinale</term>
</keywords>
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<front><div type="abstract" xml:lang="en">Piptadenia pervillei Vatke (Fabaceae) was selected from a screening programme devoted to the search of naturally-occuring antimalarial compounds from plants of Madagascar. Bioassay-guided fractionation of the ethyl acetate extract of the leaves led to the isolation of four phenolic compounds, (+)-catechin (1), (+)-catechin 5-gallate (2), (+)-catechin 3-gallate (3) and ethyl gallate (4). Structures were determined by NMR and mass spectroscopy. Compounds 2 and 3 displayed the highest in vitro activity against the chloroquine-resistant strain FcBl of Plasmodium falciparum with IC<sub>so</sub>
 values of 1.2 pM and 1.0 pM, respectively, and no significant cytotoxicity against the human embryonic lung cells MRC-5 was measured (IC<sub>50</sub>
 values >75μM). Five analogues (5-9) of (+)-catechin 5-gallate (2) were synthesized and evaluated for their antiplasmodial activity.</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
<li>Madagascar</li>
</country>
<region><li>Île-de-France</li>
</region>
<settlement><li>Gif-sur-Yvette</li>
<li>Paris</li>
</settlement>
</list>
<tree><country name="Madagascar"><noRegion><name sortKey="Ramanandraibe, Voahangy" sort="Ramanandraibe, Voahangy" uniqKey="Ramanandraibe V" first="Voahangy" last="Ramanandraibe">Voahangy Ramanandraibe</name>
</noRegion>
<name sortKey="Ramanitrahasimbola, David" sort="Ramanitrahasimbola, David" uniqKey="Ramanitrahasimbola D" first="David" last="Ramanitrahasimbola">David Ramanitrahasimbola</name>
<name sortKey="Rasoanaivo, Philippe" sort="Rasoanaivo, Philippe" uniqKey="Rasoanaivo P" first="Philippe" last="Rasoanaivo">Philippe Rasoanaivo</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Grellier, Philippe" sort="Grellier, Philippe" uniqKey="Grellier P" first="Philippe" last="Grellier">Philippe Grellier</name>
</region>
<name sortKey="Deville, Alexandre" sort="Deville, Alexandre" uniqKey="Deville A" first="Alexandre" last="Deville">Alexandre Deville</name>
<name sortKey="Joyeau, Roger" sort="Joyeau, Roger" uniqKey="Joyeau R" first="Roger" last="Joyeau">Roger Joyeau</name>
<name sortKey="Mambu, Lengo" sort="Mambu, Lengo" uniqKey="Mambu L" first="Lengo" last="Mambu">Lengo Mambu</name>
<name sortKey="Martin, Marie Therese" sort="Martin, Marie Therese" uniqKey="Martin M" first="Marie-Thérèse" last="Martin">Marie-Thérèse Martin</name>
<name sortKey="Mouray, Elisabeth" sort="Mouray, Elisabeth" uniqKey="Mouray E" first="Elisabeth" last="Mouray">Elisabeth Mouray</name>
</country>
</tree>
</affiliations>
</record>

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Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    ChloroquineV1
   |flux=    France
   |étape=   Analysis
   |type=    RBID
   |clé=     Pascal:08-0207828
   |texte=   Antiplasmodial Phenolic Compounds from Piptadenia pervillei
}}

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

Serveur d'exploration Chloroquine

Antiplasmodial Phenolic Compounds from Piptadenia pervillei

Antiplasmodial Phenolic Compounds from Piptadenia pervillei

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	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.